Association of CYP17 Gene Polymorphism with Benign Prostatic Hyperplasia
نویسندگان
چکیده
منابع مشابه
Increased risk of prostate cancer and benign prostatic hyperplasia associated with a CYP17 gene polymorphism with a gene dosage effect.
The CYP17 gene (CYP17) codes for the cytochrome P450c17alpha enzyme, which mediates two key steps in the sex steroid synthesis. There is a polymorphism (a T-to-C substitution) in the 5'-untranslated region, which may influence the transcription level of CYP17 mRNA. There is a continuing controversy as to whether the variant allele is associated with a subset of breast cancer or polycystic ovary...
متن کاملassociation of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia
background : a single nucleotide variation within atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...
متن کاملAssociation of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia
BACKGROUND A single nucleotide variation within catechol-o-methyl transferase (COMT) gene may alter the COMT enzyme activity level. Polymorphism of Val158Met in the COMT gene has been related to malignancy. In this regard, a study was carried out to find a possible association between the COMT gene polymorphism in patients with sporadic prostate cancer (PCa) and benign prostatic hyperplasia (BP...
متن کاملAssociation between Single Nucleotide Polymorphism of Vitamin D Receptor Gene FokI Polymorphism and Clinical Progress of Benign Prostatic Hyperplasia
BACKGROUND The aim of the study was to investigate the association between single nucleotide polymorphism (SNP) of vitamin D receptor (VDR) gene and clinical progress of benign prostatic hyperplasia (BPH) in Chinese men. METHODS The DNA was extracted from blood of 200 BPH patients with operation (progression group) and 200 patients without operation (control group), respectively. The genotype...
متن کاملProstate inflammation. Association with benign prostatic hyperplasia and prostate cancer.
OBJECTIVE To study the association and possible relationship of prostate inflammation with benign prostatic hyperplasia (BPH), and prostate cancer. METHODS The medical records and pathological findings of all Saudi patients who underwent transrectal ultrasound guided prostatic needle biopsies in King Abdulaziz University Medical City, Jeddah,Kingdom of Saudi Arabia from June 2003 to June 2008...
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ژورنال
عنوان ژورنال: Scholars Journal of Applied Medical Sciences
سال: 2016
ISSN: 2347-954X,2320-6691
DOI: 10.21276/sjams.2016.4.7.70